Process Chemistry

Merck Frosst offers an extraordinary degree of freedom to think, to achieve, to publish, to make major contributions to scientific knowledge. This "research first" policy has attracted some of the world's top scientists to our drug discovery team. Over the past five years, scientists from the Merck Frosst Centre for Therapeutic Research have published close to one hundred peer-reviewed articles in scientific journals.

Here is a list of some of the most important articles for Process Chemistry:

EXAMPLES OF KEY PUBLICATIONS

O’Shea, P. D.; Chen, C.-y.; Chen, W.; Dagneau, P.; Frey, L. F.; Grabowski, E. J. J.; Marcantonio, K. M.; Reamer, R. A.; Tan, L.; Tillyer, R. D.; Roy, A.; Wang, W.; Zhao, D. Practical Asymetric Synthesis of a Potent PDE4 Inhibitor via Stereoselective Enolate Alkylation of a Chiral Aryl-Heteroaryl Secondary Tosylate. J. Org. Chem. 2005, 70, 3021.

Gosselin, F.; O’Shea, P. D.; Roy, S.; Reamer, R. A.; Chen, C.-y.; Volante, R. P. Unprecedented Catalytic Asymmetric Reduction of N-H Imines. Org. Lett. 2005, 7, 355.

Gosselin, F.; Roy, A.; O’Shea, P. D.; Chen, C.-y.; Volante, R. P. Oxazolidine Ring Opening and Isomerization to (e)-Imines. Asymmetric Synthesis of Aryl-α-fluoroalkyl Amino Alcohols. Org. Lett. 2004, 6, 641.

Bolshan, Y.; Chen, C.-y.; Chilenski; J. R.; Gosselin, F.; Mathre, D. J.; O’Shea, P. D.; Roy, A.’ Tillyer, R. D. Nucleophilic Displacement at Benzhydryl Centers: Asymmetric Synthesis of 1,1-Diarylalkyl Derivatives. Org. Lett. 2004, 6, 111.

Chen, C.-y.; Dagneau, P.; Grabowski, E. J. J.; Oballa, R.; O’Shea, P. D.; Prasit, P.; Robichaud, J.; Tillyer, R. D.; Wang, X. Practical Asymmetric Synthesis of a Potent Cathepsin K Inhibitor. Efficient Palladium Removal Following Suzuki Coupling. J. Org. Chem. 2003, 68, 2633.

Tan, L.; Chen, C.-y.; Chen, W.; Frey, L. F.; King, A. O.; Tiller, R. D.; Xu, F.; Zhao, D.; Grabowski, E. J. J.; Reider, P. J.; O’Shea, P. D.; Dagneau, P.; Wang, X. Practical Enantioselective Synthesis of a COX-2 Specific Inhibitor. Tetrahedron 2002, 58, 7403.