Publication Lists

Chemists, biologists, pharmacologists, and clinicians are part of a hundred-year tradition of teamwork and scientific innovation. In addition to publishing in esteemed peer-reviewed journals, Merck Frosst scientists have won prestigious awards acknowledging their important contribution to worldwide pharmaceutical research.

Biological Sciences student-authored papers that have been published:

Slipetz, Deborah, Stephanie Buchanan, Cameron Mackereth, Natalie Brewer, Vanessa Pellow, Chuan-ming Hao, Mohammed Adam, Mark Abramovitz, and Kathleen M. Metters. "Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail." Biochem. Pharmacol. 62 (2001): 997-1012 .

Roy, Sophie, Christopher I. Bayly, Yves Gareau, Vicky M. Houtzager, Stacia Kargman, Sabina L. C. Keen, Kathleen Rowland, Isolde M. Seiden, Nancy A. Thornberry, and Donald W. Nicholson. "Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide." Proc. Natl. Acad. Sci. U. S. A. 98 (2001): 6132-37.

Liu, Susana, France Laliberté, Brian Bobechko, Adrienne Bartlett, Paula Lario, Elise Gorseth, Jonathan Van Hamme, Michael J. Gresser, and Zheng Huang. "Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors." Biochemistry 40 (2001): 10179-86.

Ducret A, Desponts C, Desmarais S, Gresser MJ, Ramachandran C. "A general method for the rapid characterization of tyrosine-phosphorylated proteins by mini two-dimensional gel electrophoresis. Electrophoresis (2000) 21, 2196-2208,

Percival, M.D., Ouellet, M., Campagnolo, C., Claveau, D., Li, C. "Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid." Biochemistry (1999) 38: 13574-83.

Elchebly, Mounib, Paul Payette, Eva Michaliszyn, Wanda Cromlish, Susan Collins, Ailsa Lee Loy, Denis Normandin, Alan Cheng, Jean Himms-Hagen, Chi-Chung Chan, Chidambaram Ramachandran, Michael J. Gresser, Michel L. Tremblay, and Brian P. Kennedy*. "Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1ß Gene." Science (1999) 283: 1544-48.

Gervais F.G., D. Xu, G.S. Robertson, J.P. Vaillancourt, Y. Zhu, JQ Huang, A. LeBlanc, D. Smith, M. Rigby, M.S. Shearman, E.E Clarke, H. Zheng, L.H. Van Der Ploeg, S.C. Ruffolo, N.A. Thornberry, S. Xanthoudakis, R.J. Zamboni, S. Roy, and D.W. Nicholson. . Involvement of caspases in proteolytic cleavage of Alzheimer's Beta-Amyloid precursor protein and amyloidogenic Beta-peptide formation. Cell (1999) 97: 395-406.

V. Houtzager, M. Ouellet, J.-P. Falgueyret, L. A. Passmore, C. Bayly and M. D. Percival. "Inhibitor-Induced Changes in the Intrinsic Fluorescence of Human Cyclooxygenase-2". Biochemistry (1996), 35, 10974-10984.

Medicinal Chemistry student-authored papers that have been published:

N. Lachance, M. April, M.-A. Joly Synlett, 2571, 2005
R. Oballa, R. Carson, S. Lait, J. Cadieux Tetradedron 61, 2761, 2005
M. Belley, Z. Douida, J. Mancuso, M. de Vleeschauwer Synlett, 247, 2005
M. Belley, K. Houde et al. Bioorg. Med. Chem. Lett. 15, 527, 2005
M. Girard, P. Murphy Tetrahedron Lett. 46, 2449, 2005
J.-F. Lévesque, M. Gaudreault et al. Steroids 70, 305, 2005
J.-F. Lévesque, E. Tempelton et al. Anal. Chem. 77, 3164, 2005
L. Li, N. Navasero Org. Lett. 6, 3091, 2005

F. Gosselin, S. Roy et al. Org. Lett. 6, 641, 2004
C. K. Lau, S. Crumpler, K. Macfarlane, F. Lee Synlett 2281, 2004
C. Drouin, J. Woo, B. MacKay, R. Lavigne Tetrahedron Lett. 45, 7197, 2004
Y. Bolshan, F. Gosselin et al. Org. Lett. 6, 111, 2004
K. Bateman, J. Baker, M. Wilke, J. Lee et al. Chem. Res. Toxicol. 17, 1356, 2004
P. Beaudette, K. Bateman J. Chromatography B, 809, 153, 2004
D. Nicoll-Griffith, M. D'Antoni et al. Drug Metab. Disp. 32, 1509, 2004

L. Li, A. Martins Tetrahedron Lett. 44, 5987, 2003
J. Woo, B. MacKay Tetrahedron Lett. 44, 2881, 2003
Y. Gareau, J. Pelicelli, D. Gauvreau et al. Tetrahedron Lett. 44, 7821, 2003
P. Zakrzewski, C. K. Lau Synlett 215, 2003
S. Surprenant, W. Y. Chan, C. Berthelette Org. Lett. 5, 4851, 2003
E. Grimm, J.-L. Methot, M. Shamji Pure Appl. Chem. 75, 231, 2003
N. Lachance, W. Y. Chan J. Heterocyclic Chem. 40, 289, 2003
L. Li, A. Martins Tetrahedron Lett. 44, 689, 2003
N. Chauret, L. Sleno et al. Cytochrome P450, Biochem. Biophysics and Drug Metab. 157, 2003

J. Baskin, Z. Wang Org. Lett. 4, 4423, 2002
J. Colucci, D. Lee, A. Chau Org. Lett. 4, 4705, 2002
C. Dufresne, D. Cretney, V. Mascitti et al. Tetrahedron Asymmetry 13, 1965, 2002
J.-L. Methot, L. Morency, P. Ramsden, J. Wong, S. Léger Tetrahedron Lett. 43, 1147, 2002
P.-L. Girard-Lauriault, M. Boyd Tetrahedron Lett. 43, 2167, 2002
W. Y. Chan, C. Berthelette Tetrahedron Lett. 43, 4537, 2002
J. Baskin, Z. Wang Tetrahedron Lett. 43, 8479, 2002
J.-F. Lévesque, M. Gaudreault et al. J. Chromatography B, 780, 145, 2002
C.-S. Li, E. Lacasse Tetrahedron Lett. 43, 3565, 2002

M. Belley, P. Dubé, S. Dolman Synlett 222, 2001
N. Chauret, B. Dobbs, R. Lackma et al. Drug Metab. Disp. 29, 1196, 2001
Y. Gareau, M. Tremblay, D. Gauvreau et al. Tetrahedron 57, 5739, 2001
Y. Leblanc, R. Carson, L. Morency et al. Tetrahedron Asymmetry 12, 3063, 2001

Process Chemistry student-authored papers that have been published:

Gosselin, F.; O'Shea, P. D.; Roy, S.; Reamer, R. A.; Chen, C.-y.; Volante, R. P. Unprecedented Catalytic Asymmetric Reduction of N-H Imines. Org. Lett. 2005, 7, 355.

Bolshan, Y.; Chen, C.-y.; Chilenski; J. R.; Gosselin, F.; Mathre, D. J.; O'Shea, P. D.; Roy, A.' Tillyer, R. D. Nucleophilic Displacement at Benzhydryl Centers: Asymmetric Synthesis of 1,1-Diarylalkyl Derivatives. Org. Lett. 2004, 6, 111.

Wang X., Rabbat P., O'Shea P., Tillyer R., Grabowski E. J. J., Reider P. J., Selective monolithiation of 2,5-dibromopyridine with butyllithium, Tetrahedron Letters, 41, 4335, 2000

Wang X., Zak M., Maddens M., O'Shea P., Tillyer R., Grabowski E. J. J., Reider P. J., Highly asymmetric dihydroxylation of 1-aryl-1'-pyridyl alkenes. Tetrahedron Letters, 41, 4865, 2000

Pharmaceutical R&D student-authored papers that have been published:

Hancock, B. C., K. Christensen, and S. L. Shamblin. "Estimating the critical molecular mobility temperature." Pharmaceut. Res. 15 (1998): 1649-51.

Hancock, B. C., Y. Dupuis, and R. Thibert. "Determination of the viscosity of an amorphous drug using thermomechanical analysis (TMA)." Pharmaceut. Res. 16 (1999): 672-75.