| 1. | Merck Frosst Canada - Welcome to the Scientist's Section |
| | Efforts in the leukotriene programs have yielded one highly effective and innovative medicine : the leukotriene D4 receptor antagonist SINGULAIR® (montelukast sodium) for bronchial asthma in adults and children as young as six.... |
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| 2. | Merck Frosst Canada - Major Accomplishments Overview |
| | With the development of ® (montelukast sodium), the Merck Frosst Centre for Therapeutic Research has earned its place as one of the world's leading research centres.... |
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| 3. | Merck Frosst Canada - Local Perspective |
| | Scientific research at the Merck Frosst Centre for Therapeutic Research in Montréal has in the past focused primarily on inflammatory and respiratory diseases, leading to the discovery, among others, of SINGULAIR® (montelukast sodium).... |
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| 4. | Merck Frosst Canada - SINGULAIR® |
| | SINGULAIR® (montelukast sodium) is a significant innovation in the treatment of asthma.... Both approaches yielded good results over the next 10 years ; however, by 1991 it was clear that montelukast sodium (later to become SINGULAIR®) was the superior drug and the inhibition approach was finally dropped.... |
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| 5. | Merck Frosst Canada - Respiratory Diseases |
| | Many seeds of fruitful research projects were planted during the 20 - year development history of SINGULAIR® (montelukast sodium), the first once-a-day oral asthma medication for adults and children as young as six.... |
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| 6. | Merck Frosst Canada - Biochemistry |
| | An on-going program to identify ligands of orphan GPCRs identified the cys-LT1 receptor for SINGULAIR® (montelukast sodium) (Nature 1999). ® Registered Trademark of Merck & Co, Inc Used under license.... |
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| 7. | Merck Frosst Canada - Drug Metabolism |
| | For the SINGULAIR® (montelukast sodium) programs, human metabolites were identified and tested even before the drug was administered to people.... |
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| 8. | Merck Frosst Canada - NMR Spectroscopy |
| | The NMR team at the Merck Frosst Centre for Therapeutic Research was involved in the identification of the majority of the metabolites generated during the development of SINGULAIR® (montelukast sodium), which was critical in preventing potential problems in the drug development process.... |
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| 9. | Merck Frosst Canada - Clinical Supplies |
| | SINGULAIR® (montelukast sodium) developed here at Merck Frosst and currently marketed worldwide, still represent about 50 % of the clinical supply effort in the form of post-marketing trials, and the development of new indications and new formulations.... |
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| 10. | Merck Frosst Canada - SINGULAIR® |
| | Merck Frosst Canada - SINGULAIR®PrSINGULAIR® (montelukast sodium tablets) (montelukast sodium chewable tablets) (montelukast sodium granules for oral use)Original Notice of Compliance (NoC). |
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