| 1. | Merck Frosst Canada - Major Accomplishments Overview |
| | Their work resulted in the launch of SINGULAIR® in Canada in 1998, a revolutionary once-a-day tablet for asthma for patients as young as six, and made the Merck Frosst Centre for Therapeutic Research a leader in leukotriene research. for the Merck Frosst Centre for Therapeutic Research include the discovery of the cardiovascular drug BLOCADREN® (timolol maleate tablets) (1974), the muscle relaxant FLEXERIL® (cyclobenzaprine hydrochloride) (1978) and TIMOPTIC® (timolol maleate ophthalmic solution) for glaucoma (1978). The Canadian site has also contributed significantly to the clinical development of FOSAMAX® (alendronate sodium) for osteoporosis, MAXALT® (rizatriptan benzoate) for migraine, AGGRASTAT® (tirofiban hydrochloride) for unstable angina, CRIXIVAN® (indinavir sulfate) for HIV / AIDS, COZAAR® Â § (losartan potassium) for hypertension and ZOCOR® (simvastatin) for lowering cholesterol. ® Registered Trademark of Merck & Co, Inc Used under license.... |
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| 2. | Merck Frosst Canada - Organic Synthesis |
| | For HIV protease inhibitor CRIXIVAN® (indinavir sulfate), for example, it is linear (chart 1), based on the discovery that the stereochemical center in intermediate 2 can be used to set three new centres in the final molecule.... |
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| 3. | Merck Frosst Canada - Partners |
| | Consistent with its commitment to increase access, in March 2001, Merck began offering its HIV / AIDS medicines CRIXIVAN® (indinavir sulfate) and STOCRIN® (efavirenz) to developing countries hardest hit by the AIDS epidemic for no profit.... |
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| 4. | Merck Frosst Canada - Caring for People Around the World |
| | Consistent with its commitment to increase access, in March 2001 Merck began offering its HIV / AIDS medicines CRIXIVAN® (indinavir sulfate) and STOCRIN® (efavirenz) to developing countries hardest hit by the AIDS epidemic for no profit.... |
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| 5. | Merck Frosst Canada - CRIXIVAN® |
| | Merck Frosst Canada - CRIXIVAN®PrCRIXIVAN® (indinavir sulfate capsules)Original Notice of Compliance (NoC). |
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| 6. | Merck Frosst Canada - HIV Disease and AIDS |
| | PrCRIXIVAN® (indinavir sulfate)... |
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