| 1. | Merck Frosst Canada - Welcome to the Scientist's Section |
| | The Merck Frosst Centre for Therapeutic Research is investing aggressively in bioinformatics, gene expression technology, drug candidate automated screening technologies, and research information technology, to increase productivity and speed the drug discovery process.... |
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| 2. | Merck Frosst Canada - Medicinal Chemistry Overview |
| | The process of coming up with a chemical structure and developing it into a drug candidate may take 10 to 12 years with over 10,000 candidate compounds rejected for every one that makes it.... |
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| 3. | Merck Frosst Canada - Process Chemistry Overview |
| | The work of the Process Chemistry de partment at the Merck Frosst Centre for Therapeutic Research begins when basic research has identified a potential new drug candidate.... |
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| 4. | Merck Frosst Canada - Organic (Medicinal) Chemistry |
| | Molecules that show promise as potential drug candidates are assayed, redesigned, and assayed again in a continuous feedback loop with Biological Sciences until a compound suitable for safety testing is identified.... The drug candidates validated the hypothesis that LTD-4played a crucial role in triggering asthma.... |
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| 5. | Merck Frosst Canada - Drug Metabolism |
| | This integration into the drug discovery process accelerates the rate at which drug candidates can be tested in human in vitro systems.... Using microsomal fractions, hepatocytes and recombinant enzymes from human sources, scientists are able to identify metabolic liabilities and reject unsuitable drug candidates early.... |
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| 6. | Merck Frosst Canada - Mass Spectrometry |
| | Mass SpectrometryThe Merck Frosst Centre for Therapeutic Research currently has 10 mass spectrometers that are used to characterize drug candidates and their metabolites.. In an innovative move, the Centre provides open-access mass spectrometers to chemists for walkup analysis.. With state-of-the-art single-quadrupole, triple-quadrupole, sector and time-of-flight instruments, the mass spectrometry team provides structural analysis of molecules ranging from molecular weight 100 to 100,000. The group studies the structures of metabolites produced by cytochrome P450s and other metabolizing enzymes as well as the structures of the enzymes themselves.. |
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| 7. | Merck Frosst Canada - Automated Parallel Synthesis |
| | It has had a tremendous impact on the way Merck Frosst designs and refines new drug candidates.... |
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| 8. | Merck Frosst Canada - Preparative (Process) Chemistry |
| | The Merck Frosst Centre for Therapeutic Research has state-of-the-art preparative laboratories for the preparation of new drug candidates.... |
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| 9. | Merck Frosst Canada - Materials Science |
| | The Materials Science group at the Merck Frosst Centre for Therapeutic Research is responsible for characterizing all potential drug candidates obtained from Medicinal Chemistry, at the outset of the drug discovery process.... |
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| 10. | Merck Frosst Canada - Process Chemistry |
| | The Process Chemistry department at Merck Frosst offers exciting career opportunities for top-class organic chemists who can meet the challenge of designing and developing innovative and practical methods for the preparation of new drug candidates.... |
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